Cantharidin-loaded biomimetic MOF nanoparticle cascade to enhance the Fenton reaction based on amplified photothermal therapy
Xiao Cheng, Ye Liu, Hao Zhou, Junke Leng, Xiaofeng Dai, Dong Wang, Kun Ma, Changhao Cui, Jijun Fu, Zhaoming Guo
Abstract
the coated macrophage cell membranes (MPCMs) to target inflammatory tissues. The photothermal effect of polypyrrole (PPy) accelerated the release of cantharidin (CTD) and iron ions loaded in the PCMM NPs. CTD, as an HSR inhibitor, could inhibit this response of tumour cells and improve the effect of PTT. Meanwhile, the heat generated during the PTT process could improve the efficiency of the Fenton reaction. This study suggested that PCMM NPs could serve as a combined treatment platform to enhance the Fenton reaction based on amplified photothermal therapy.
Topics & Concepts
Photothermal therapyChemistryCatalysisNanoparticlePhotothermal effectFenton reactionHydroxyl radicalBiophysicsChemical engineeringNanotechnologyMaterials scienceRadicalOrganic chemistryEngineeringBiologyNanoplatforms for cancer theranosticsAntimicrobial Peptides and ActivitiesMXene and MAX Phase Materials