Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N′-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction
Sumi Lee, Dhulfiqar Ali Abed, Mai-Uyen Nguyen, Michael P. Verzi, Longqin Hu
Topics & Concepts
ChemistryNaphthaleneBenzeneBenzene derivativesStereochemistryStructure–activity relationshipCrystal structureMedicinal chemistryBiochemistryOrganic chemistryIn vitroChemical synthesisGenomics, phytochemicals, and oxidative stressFree Radicals and AntioxidantsGlutathione Transferases and Polymorphisms