In vitro to in vivo translation
William B. Mattes
Abstract
The science of in vitro studies has advanced dramatically over the last 100 years, particularly in regards to their application in toxicology. Recent developments such as in vitro three-dimensional cultures and microphysiological systems have offered the promise of even greater replication of in vivo function. Nonetheless, the challenge of validating a system's performance and extrapolating it's responses to those of an animal or human remains
Topics & Concepts
In vivoIn vitroReplication (statistics)BiologyComputational biologyFunction (biology)Cell biologyBiotechnologyGeneticsVirology3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques InnovationCell Image Analysis Techniques