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Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Keisuke Yamamoto, Anthony Venida, Julian Yano, Douglas E. Biancur, Miwako Kakiuchi, Suprit Gupta, Albert S.W. Sohn, Subhadip Mukhopadhyay, Elaine Y. Lin, Seth J. Parker, Robert S. Banh, João A. Paulo, Kwun Wah Wen, Jayanta Debnath, Grace Kim, Joseph D. Mancias, Douglas T. Fearon, Rushika M. Perera, Alec C. Kimmelman

2020Nature1,232 citationsDOIOpen Access PDF

Topics & Concepts

AutophagyMajor histocompatibility complexMHC class ICancer researchImmune systemBiologyCD8Antigen presentationAntigenCell biologyT cellImmunologyApoptosisGeneticsAutophagy in Disease and TherapyPhagocytosis and Immune RegulationImmune Cell Function and Interaction
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I | Litcius