Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages
Yi Rang Na, Jung Won Kwon, Da-Young Kim, Hyewon Chung, Juha Song, Daun Jung, Hailian Quan, Daesik Kim, Jin‐Soo Kim, Young Wook Ju, Wonshik Han, Han Suk Ryu, Yun‐Sang Lee, Jung Joo Hong, Seung Hyeok Seok
Abstract
T cells by about 60-fold. Our findings demonstrate critical roles of TAM PKA-C in tumor progression and suggest that targeting PKA-C efficiently augments cancer treatment responses.
Topics & Concepts
Tumor microenvironmentCancer researchProtein kinase AProtein subunitCancer immunotherapyPhenotypeMacrophageCancerTumor-associated macrophageTumor progressionKinaseBiologyChemistryImmunotherapyCell biologyImmune systemImmunologyIn vitroBiochemistryTumor cellsGeneGeneticsImmune cells in cancerPhagocytosis and Immune RegulationCancer, Hypoxia, and Metabolism