Discovery of a potent EGFR and ALK dual mutation inhibitor containing N-(3-((4-((2-(cyclopropylsulfinyl)phenyl)amino)pyrimidin-2-yl)amino) phenyl)acrylamide scaffold
Wei Li, Han Yao, Chenxi Gu, Yuanyuan Ren, Jiadai Liu, Baijiao An, Wenhao Hu, Xingshu Li, Albert S. C. Chan
Topics & Concepts
ChemistryApoptosisPhosphorylationAcrylamideIn vivoDimethyl sulfoxideIn vitroCell cycle checkpointBiochemistryCancer researchCell biologyCell cycleOrganic chemistryCopolymerPolymerBiotechnologyBiologyLung Cancer Treatments and MutationsCancer therapeutics and mechanismsBiochemical and Molecular Research