Identification, optimization, and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein
Hui Li, Chen Cheng, Shanshan Shi, Yan Wu, Yongfeng Gao, Zhihao Liu, Mingjian Liu, Zhaodong Li, Lijian Huo, Xiaoyan Pan, Shuwen Liu, Gaopeng Song
Topics & Concepts
Vero cellChemistryVirologyLead compoundCoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Lipid bilayer fusionVirusCoronavirus disease 2019 (COVID-19)Computational biologyIn vitroBiochemistryBiologyInfectious disease (medical specialty)MedicineDiseasePathologySARS-CoV-2 and COVID-19 Researchinterferon and immune responsesMosquito-borne diseases and control