Silver‐catalyzed Cascade Bis‐heteroannulation Reaction of Enynones and <i>o</i>‐Hydroxyphenyl Enaminones: Access to Highly Functionalized 3‐Furylmethyl Chromones
Mingshuai Zhang, Meichen Liu, Yuetong Qiu, Menglin Peng, Zhilai Zhang, Siyu Song, Xuebing Chen, Fuchao Yu
Abstract
Abstract A synthetic protocol was developed to synthesize highly functionalized 3‐furylmethyl chromones from enynones and o ‐hydroxyphenyl enaminones via silver‐catalyzed cascade bis‐heteroannulation reaction. This strategy features broad substrate scope and good functional group tolerance. Furthermore, the 3‐furylmethyl chromone skeleton shows the potential synthetic application value through further gram‐scale synthesis and derivatization.
Topics & Concepts
ChemistryCatalysisCascadeCascade reactionCombinatorial chemistryOrganic chemistryMedicinal chemistryChromatographySynthesis of Organic CompoundsCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods