Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of <i>Bifidobacterium bifidum</i> to inflammatory bowel disease
Jun Liu, Ronghao Lu, Xiaolin Zheng, Wensheng Hou, Xiaoying Wu, Hezhao Zhao, Guixue Wang, Tian Tian
Abstract
Numerical simulations were applied to guide the design of a gut-on-a-chip device with controllable oxygen gradients. Bifidobacterium bifidum was demonstrated to increase the stability of the intestinal epithelial barrier on the disease model.
Topics & Concepts
Bifidobacterium bifidumOrgan-on-a-chipBifidobacteriumCell biologyInflammatory bowel diseaseChemistryMicrofluidicsBiologyNanotechnologyMaterials scienceMedicineLactobacillusPathologyDiseaseBiochemistryFermentation3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques InnovationMicrofluidic and Bio-sensing Technologies