Facile construction of spiroindoline derivatives as potential anti-viral agent via three-component reaction in aqueous with β-cyclodextrin-SO<sub>3</sub>H as an efficient catalyst
Fangzhou Xu, Yanyan Wang, Feng He, Zelian Li, Shengxin Guo, Yun Xie, Dexia Luo, Jian Wu
Abstract
A convenient and efficient β-cyclodextrin-SO3H-assisted strategy for construction of spiro indoline derivatives in aqueous media was disclosed. The present protocol showed various advantages including short reaction time, broad scope of substituents, simplicity of practice, high yields of products, recyclability of catalysts, safety, and cheapness of benign solvents. Preliminary study indicated that some of spiroindoline derivatives exhibited anti-Tobacco Mosaic Virus (TMV) activity for potential use in plant protection.
Topics & Concepts
ChemistryCyclodextrinCatalysisTobacco mosaic virusAqueous mediumCombinatorial chemistryIndolineAqueous solutionOrganic chemistryVirusVirologyBiologyMulticomponent Synthesis of HeterocyclesSynthesis and biological activityClick Chemistry and Applications