Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure
Dallan McMahon, Wendy Oakden, Kullervo Hynynen
Abstract
: These results suggest that DEX provides a means of modulating the duration of BBB permeability enhancement and may reduce the risk of inflammation-induced tissue damage, increasing the safety profile of this drug-delivery strategy. This effect may be especially relevant in scenarios for which the goal of treatment is to restore or preserve neural function and multiple sonications are required.
Topics & Concepts
MicrobubblesBlood–brain barrierDexamethasoneMedicineVascular permeabilitySonicationUltrasoundAstrocyteInflammationPermeability (electromagnetism)PathologyPharmacologyInternal medicineChemistryCentral nervous systemRadiologyBiochemistryMembraneUltrasound and Hyperthermia ApplicationsPhotoacoustic and Ultrasonic ImagingUltrasound Imaging and Elastography