Dysideanones F—G and dysiherbols D—E, unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara
Hong-Yan LIU, Mi ZHOU, Ru-Yi SHANG, Li-Li HONG, Guang-Hui WANG, Wen-Jing TIAN, Wei-Hua JIAO, Hai-Feng CHEN, Hou-Wen LIN
Abstract
Four new sesquiterpene quinone meroterpenoids, dysideanones F—G ( 1 — 2 ) and dysiherbols D—E ( 3 — 4 ), were isolated from the marine sponge Dysidea avara collected from the South China Sea. The new structures were elucidated by extensive analysis of spectroscopic data including HR-MS and 1D and 2D NMR spectra, and their absolute configurations were assigned by single-crystal X-ray diffraction and ECD calculations. Anti-inflammatory evaluation showed that dysiherbols D—E ( 3 — 4 ) exhibited moderate inhibitory activity on TNF- α -induced NF- κ B activation in human HEK-293T cells with IC 50 values of 10.2 and 8.6 μmol·L —1 , respectively.