Nitric oxide-primed engineered extracellular vesicles restore bioenergetics in acute kidney injury via mitochondrial transfer
Fei Peng, Xiaoniao Chen, Lingling Wu, Jiayi He, Zongjin Li, Quan Hong, Qiang Zhao, Meng Qian, Xu Wang, Wanjun Shen, Tingting Qi, Yiyu Huang, Guangyan Cai, Chuyue Zhang, Xiangmei Chen
Abstract
Our study elucidated a mitochondria-targeted therapeutic strategy enabled by engineered EVs that deliver functional cargo to restore mitochondrial homeostasis. These advances provide transformative potential for AKI and other mitochondrial disorders.
Topics & Concepts
BioenergeticsExtracellular vesiclesNitric oxideAcute kidney injuryMitochondrionCell biologyExtracellularChemistryNitric oxide synthaseBiophysicsMedicineBiologyInternal medicineOrganic chemistryExtracellular vesicles in diseaseAdvanced Nanomaterials in CatalysisRenal and Vascular Pathologies