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Preclinical evaluation and pilot clinical study of [68Ga]Ga-THP-APN09, a novel PD-L1 targeted nanobody radiotracer for rapid one-step radiolabeling and PET imaging

Xiaopan Ma, Xin Zhou, Biao Hu, Xiaoda Li, Meinan Yao, Liqiang Li, Xue Qin, Dapeng Li, Yuan Yao, Xingguo Hou, Song Liu, Yan Chen, Zilei Wang, Wenyuan Zhou, Nan Li, Hua Zhu, Bing Jia, Zhi Yang

2023European Journal of Nuclear Medicine and Molecular Imaging36 citationsDOI

Topics & Concepts

BiodistributionRadiosynthesisA549 cellFlow cytometryImaging agentImmunotherapyNuclear medicineCancer researchRadioimmunotherapyMedicineCell cultureCellAdjuvantLung cancerPositron emission tomographyChemistryMonoclonal antibodyPathologyCancerIn vivoAntibodyIn vitroOncologyImmunologyInternal medicineBiologyBiotechnologyGeneticsBiochemistryCancer Immunotherapy and BiomarkersNanoplatforms for cancer theranosticsRadiopharmaceutical Chemistry and Applications
Preclinical evaluation and pilot clinical study of [68Ga]Ga-THP-APN09, a novel PD-L1 targeted nanobody radiotracer for rapid one-step radiolabeling and PET imaging | Litcius