Designed DNA nanostructure grafted with erlotinib for non-small-cell lung cancer therapy
Yuqi Wang, Jin Cheng, Di Zhao, Yan Liu, Tao Luo, Yi-Fang Zhong, Fangli Mo, Xiangyang Kong, Jie Song
Abstract
) modified DNA strands and subsequently self-assembled on spatially programmable erlotinib-grafted 6 × 6 × 64 nt DNA nanostructures. Thus, Er was successfully grafted on DNA carriers and transformed into a hydrophilic formulation. The antitumor efficacy was evaluated both in vitro and in vivo, and enhanced cytotoxicity toward A549 cells and the marked inhibition of tumor growth for non-small-cell lung cancer (NSCLC) were observed.
Topics & Concepts
ErlotinibLung cancerNanostructureCancer researchCellDNAMaterials scienceMedicineNanotechnologyOncologyCancerEpidermal growth factor receptorInternal medicineChemistryBiochemistryAdvanced biosensing and bioanalysis techniquesNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery