Emodin ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through the remodeling of gut microbiota composition
Songqing Hu, Jiedong Zhou, Jinjin Hao, Zuoquan Zhong, Haowei Wu, Peipei Zhang, Juntao Yang, Hangyuan Guo, Jufang Chi
Abstract
This study demonstrated for the first time the protective effect of emodin against DIC and verified by FMT that its cardioprotective effect was achieved by remodeling gut microbiota composition, resulting in attenuation of ferroptosis. Furthermore, we demonstrated that these effects were mediated by the redox-related gene Nrf2.
Topics & Concepts
CardiotoxicityDoxorubicinEmodinGut floraComposition (language)ChemistryPharmacologyBiologyBiochemistryToxicityChemotherapyGeneticsOrganic chemistryLinguisticsPhilosophyGenomics, phytochemicals, and oxidative stressGDF15 and Related BiomarkersFerroptosis and cancer prognosis