Innovative localized surface plasmon resonance sensing technique for a green spectrofluorimetric assay of ketoprofen, paracetamol and chlorzoxazone in pharmaceutical preparations and biological fluids
Nora A. Abdallah, Mona E. Fathy, Manar M. Tolba, Amina M. El-Brashy, Fawzia Ibrahim
Abstract
for KPN, PAR and CLX, respectively. Validity of the proposed method was investigated according to ICH recommendations. The proposed technique was also employed for the analysis of each of the three drugs in commercial or laboratory prepared tablets and in spiked human plasma with very good recoveries as well as high level of accuracy and precision. This method was intended to the analysis of the proposed drugs in their single formulation and single drug administration. The suggested technique is considered an eco-friendly method, as it uses water as the safest and least expensive solvent. Moreover, the recommended technique does not involve solvent extraction of the formed complexes. Greenness assessment of the suggested procedure was accomplished by applying the four standard assessment tools. Consequently, the recommended method can be used in the routine quality control analysis of the cited drugs with minimum harmful effect on the environment as well as the individuals.