Design, synthesis, and biological evaluation of novel tryptanthrin derivatives as selective acetylcholinesterase inhibitors for the treatment of Alzheimer's disease
Jucheng Xia, Shuanghong Dong, Lili Yang, Fang Wang, Siqi Xing, Jiyu Du, Zeng Li
Topics & Concepts
ButyrylcholinesteraseAcetylcholinesteraseChemistryCholinesteraseIn vivoPharmacologyAchéAmyloid betaNeuroprotectionBiochemistryEnzymePeptideBiologyMedicineBiotechnologyCholinesterase and Neurodegenerative DiseasesPhosphodiesterase function and regulationPhenothiazines and Benzothiazines Synthesis and Activities