Influence of Patient Age on the Biological Profile and Prognosis of Operable Early-Stage Breast Cancer
P. Rojas, M. Soto, I. Vargas
Abstract
Breast cancer (BC) exhibits age-related alterations in its biological characteristics. This study aimed to investigate the natural progression of these changes. A total of 2,383 women with clinically T0-2N0-1M0 BC, treated with primary surgery and appropriate adjuvant therapy at a specialized BC center, were included. Tissue microarrays were prepared from surgical specimens, and indirect immunohistochemistry was performed to assess a comprehensive panel of 16 relevant biomarkers. Significant dec
Topics & Concepts
MedicineBreast cancerOncologyInternal medicineTissue microarrayImmunohistochemistryAdjuvantAdjuvant therapyCancerStage (stratigraphy)Natural historyMammary glandGynecologyMastectomySurgeryAdjuvant chemotherapyPathologyBreast tissueOverall survivalChemotherapyCA15-3Neoplasm stagingBreast Cancer Treatment StudiesHER2/EGFR in Cancer ResearchGlobal Cancer Incidence and Screening