Synthesis and biological evaluation of 5-chalcogenyl-benzo[<i>h</i>]quinolines <i>via</i> photocyclization of arylethynylpyridine derivatives
Thiago J. Peglow, Carolina C. Martins, Ketlyn P. da Motta, Cristiane Luchese, Ethel A. Wilhelm, Rafael Stieler, Paulo H. Schneider
Abstract
A new method for the synthesis of benzo[ h ]quinolines 5-chalcogenyl-functionalized via visible light-promoted intramolecular ortho -cyclization was described. Furthermore, studies have suggested that this class of compounds may have promising therapeutic potential.
Topics & Concepts
ChemistryIntramolecular forceCombinatorial chemistryStereochemistryMedicinal chemistryRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods