Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries
Miljan Kuljanin, Dylan C. Mitchell, Devin K. Schweppe, Ajami Gikandi, David P. Nusinow, Nathan J. Bulloch, Ekaterina V. Vinogradova, David L. Wilson, Eric T. Kool, Joseph D. Mancias, Benjamin F. Cravatt, Steven P. Gygi
Topics & Concepts
CysteineProteomeComputational biologyProfiling (computer programming)ChemistryBiochemistryBruton's tyrosine kinaseKRASBiologyTyrosine kinaseComputer scienceSignal transductionGeneMutationEnzymeOperating systemClick Chemistry and ApplicationsPeptidase Inhibition and AnalysisChemical Synthesis and Analysis