Cannabidiol attenuates pulmonary arterial hypertension by improving vascular smooth muscle cells mitochondrial function
Xiaohui Lü, Jingyuan Zhang, Huijiao Liu, Wenqiang Ma, Leo Yu, Xin Tan, Shubin Wang, Fazheng Ren, Xiru Li, Xiangdong Li
Abstract
Taken together, these findings confirm an important role for CBD in PAH pathobiology.
Topics & Concepts
CannabidiolPharmacologyOxidative stressHypoxia (environmental)Reactive oxygen speciesPulmonary hypertensionCannabinoidIn vivoInflammationMitochondrionMedicineApoptosisChemistryPulmonary arteryMitochondrial ROSCancer researchInternal medicineBiologyReceptorBiochemistryOxygenCannabisPsychiatryBiotechnologyOrganic chemistryCardiovascular Function and Risk FactorsMitochondrial Function and PathologyDiet, Metabolism, and Disease