Mn(II) Optimized Sono/Chemodynamic Effect of Porphyrin‐Metal–Organic Framework Nanosheets for MRI‐Guided Colon Cancer Therapy and Metastasis Suppression
Lifeng Hang, Meng Li, Yuxuan Zhang, Wuming Li, Laiping Fang, Yiyu Chen, Chunze Zhou, Hong Qu, Lianyi Shao, Guihua Jiang
Abstract
Abstract Sonodynamic therapy (SDT) offers a remarkable non‐invasive ultrasound (US) treatment by activating sonosensitizer and generating reactive oxygen species (ROS) to inhibit tumor growth. The development of multifunctional, biocompatible, and highly effective sonosensitizers remains a current priority for SDT. Herein, the first report that Mn(II) ions chelated Gd‐TCPP (GMT) nanosheets (NSs) are synthesized via a simple reflux method and encapsulated with pluronic F‐127 to form novel sonosensitizers (GMTF). The GMTF NSs produce a high yield of ROS under US irradiation due to the decreased highest occupied molecular orbital−lowest unoccupied molecular orbital gap energy (2.7–1.28 eV). Moreover, Mn(II) ions endow GMTF with a fascinating Fenton‐like activity to produce hydroxyl radicals in support of chemodynamic therapy (CDT). It is also effectively used in magnetic resonance imaging (MRI) with high relaxation rate ( r 1 : 4.401 mM −1 s −1 ) to track the accumulation of NSs in tumors. In vivo results indicate that the SDT and CDT in combination with programmed cell death protein 1 antibody (anti‐PD‐1) show effective metastasis prevention effects, and 70% of the mice in the GMTF + US + anti‐PD‐1 group survived for 60 days. In conclusion, this study develops a sonosensitizer with promising potential for utilizing both MRI‐guided SDT and CDT strategies.