Newer Therapeutic Approaches in Treating Alzheimer’s Disease: A Comprehensive Review
Radhakrishna Reddi Sree, Manjunath Kalyan, Nikhilesh Anand, Sangeetha Mani, Vasavi Rakesh Gorantla, Meena Kishore Sakharkar, Byoung‐Joon Song, Saravana Babu Chidambaram
Abstract
-methyl-d-aspartate (NMDA) antagonist. These treatment strategies focus on only symptomatic management of AD by attenuating symptoms but not regeneration of neurons or clearance of Aβ plaques and hyperphosphorylated Tau. This review focuses on the pathophysiology, novel therapeutic targets, and disease-altering treatments such as α-secretase modulators, active immunotherapy, passive immunotherapy, natural antioxidant products, nanomaterials, antiamyloid therapy, tau aggregation inhibitors, transplantation of fecal microbiota or stem cells, and microtubule stabilizers that are in clinical trials or still under investigation.