The interplay between chromatin remodeling and DNA double-strand break repair: Implications for cancer biology and therapeutics
Liu‐Jun He, Jaeyoung Moon, Chenghui Cai, Yalan Hao, Hyorin Lee, Wootae Kim, Fei Zhao, Zhenkun Lou
Abstract
Proper chromatin remodeling is crucial for many cellular physiological processes, including the repair of DNA double-strand break (DSB). While the mechanism of DSB repair is well understood, the connection between chromatin remodeling and DSB repair remains incompletely elucidated. In this review, we aim to highlight recent studies demonstrating the close relationship between chromatin remodeling and DSB repair. We summarize the impact of DSB repair on chromatin, including nucleosome arrangement, chromatin organization, and dynamics, and conversely, the role of chromatin architecture in regulating DSB repair. Additionally, we also summarize the contribution of chromatin remodeling complexes to cancer biology through DNA repair and discuss their potential as therapeutic targets for cancer. • A comprehensive review of the interplay between chromatin remodeling and DNA double-strand break (DSB) repair. • A detailed exploration of how histone modifications and chromatin architecture influence DSB repair pathways. • A focus on the role of chromatin remodelers as critical regulators of genome stability and their implications in cancer progression. • A discussion on targeting chromatin remodeling complexes as potential therapeutic strategies for cancer treatment.