Multi-omics study reveals that statin therapy is associated with restoration of gut microbiota homeostasis and improvement in outcomes in patients with acute coronary syndrome
Xiaomin Hu, Hanyu Li, Xinyue Zhao, Ruilin Zhou, Honghong Liu, Yueshen Sun, Yue Fan, Yanan Shi, Shanshan Qiao, Shuang‐Jiang Liu, Hongwei Liu, Shuyang Zhang
Abstract
Our study suggests that statin treatment might benefit ACS patients by modulating the composition and function of the gut microbiome, which might result in improved circulating metabolites and reduced metabolic risk. Our findings provide new insights for understanding the heterogenic roles of statins in ACS patients through host gut microbiota metabolic interactions.
Topics & Concepts
Acute coronary syndromeMedicineGut floraCoronary artery diseaseOmicsStatinInternal medicineCardiologyBioinformaticsImmunologyMyocardial infarctionBiologyGut microbiota and healthMetabolomics and Mass Spectrometry StudiesInfective Endocarditis Diagnosis and Management