Unlike LGR4, LGR5 potentiates Wnt–β-catenin signaling without sequestering E3 ligases
Soo-Hyun Park, Ling Wu, Jianghua Tu, Wangsheng Yu, Yukimatsu Toh, Kendra S. Carmon, Qingyun J. Liu
Abstract
in organ development, as well as the self-renewal and fitness of adult stem cells.
Topics & Concepts
LGR5Wnt signaling pathwayUbiquitin ligaseCell biologyLRP6Stem cellBiologyUbiquitinSignal transductionReceptorBiochemistryGeneCancer Cells and MetastasisWnt/β-catenin signaling in development and cancerDigestive system and related health