Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs
Xue-Mei Zheng, Yuan-Si Chen, Yu-Juan Ban, Yujie Wang, Yongxi Dong, Lei Li, Bing Guo, Jianta Wang, Lei Tang, Hongliang Li, Jiquan Zhang
Topics & Concepts
ChemistryPI3K/AKT/mTOR pathwayIC50Colorectal cancerPharmacologyBenzoxazoleCell growthKinaseCell cultureIn vitroCancer researchSignal transductionBiochemistryCancerInternal medicineMedicineBiologyGeneticsOrganic chemistryPI3K/AKT/mTOR signaling in cancerChronic Lymphocytic Leukemia ResearchBiochemical and Molecular Research