SIRT4 promotes neuronal apoptosis in models of Alzheimer’s disease via the STAT2–SIRT4–mTOR pathway
Dianxia Xing, Wenjin Zhang, Wei Cui, Xiuya Yao, Yaping Xiao, Lihua Chen, Shiyun Yuan, Yanyan Duan, Weihua Yu, Pengfei Pan, Yang Lü
Abstract
The study reveals that in Alzheimer's disease models, SIRT4 expression increases, contributing to neuronal apoptosis and amyloid-β deposition. Reducing SIRT4 lessens apoptosis and amyloid-β accumulation, improving memory in mice. This process involves the mTOR pathway, regulated by STAT2 transcription factor. These findings suggest targeting the STAT2-SIRT4-mTOR axis as a potential Alzheimer's treatment strategy.
Topics & Concepts
SirtuinApoptosisWestern blotPI3K/AKT/mTOR pathwayDiseaseBiologyAlzheimer's diseaseProgrammed cell deathDementiaCancer researchNeuroscienceCell biologyMedicinePathologyBiochemistryEnzymeGeneNAD+ kinaseSirtuins and Resveratrol in MedicineBiochemical effects in animalsTryptophan and brain disorders