Litcius/Paper detail

CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours

Rebecca C. Larson, Michael C. Kann, Stefanie R. Bailey, Nicholas J. Haradhvala, Paula Montero Llopis, Amanda A. Bouffard, Irene Scarfò, Mark B. Leick, Korneel Grauwet, Trisha R. Berger, Kai Stewart, Praju Vikas Anekal, Max Jan, Julia Joung, Andrea Schmidts, Tamara Ouspenskaia, Travis Law, Aviv Regev, Gad Getz, Marcela V. Maus

2022Nature351 citationsDOI

Topics & Concepts

Chimeric antigen receptorCancer researchBiologyCytotoxic T cellCytotoxicityCD8T cellAntigenCell biologyImmunologyIn vitroImmune systemGeneticsCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsCRISPR and Genetic Engineering