Chiral <i>gem</i>-difluoroalkyl reagents: <i>gem</i>-difluoroalkyl propargylic borons and <i>gem</i>-difluoroalkyl α-allenols
Hui-Na Zou, Meng-Lin Huang, Ming‐Yao Huang, Yu‐Xuan Su, Jingwei Zhang, Xinyu Zhang, Shou‐Fei Zhu
Abstract
Two types of chiral gem -difluoroalkyl reagents, chiral gem -difluoroalkyl propargylic borons and gem -difluoroalkyl α-allenols were developed by means of Rh-catalyzed enantioselective B–H bond insertion and Lewis acid-promoted allenylation.
Topics & Concepts
ReagentFunctional groupCombinatorial chemistryChemistryEnantioselective synthesisMoleculeStereochemistryCatalysisOrganic chemistryPolymerFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods