Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders
Weiting Tang, Ding Liu, Stephen F. Traynelis, Hongjie Yuan
Topics & Concepts
Allosteric regulationNMDA receptorAllosteric modulatorPregnenolone sulfateNeuroscienceReceptorGlutamate receptorEpilepsyExcitatory postsynaptic potentialPharmacologyLoss functionBiologyGABAA receptorChemistryPhenotypeGeneGeneticsNeuroactive steroidAmino Acid Enzymes and MetabolismNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders