Formulation and evaluation of PVA-based composite hydrogels: physicochemical, leachables, and <i>in vitro</i> immunogenicity studies
Achmad Himawan, Anna Korelidou, Ana M. Pérez‐Moreno, Juan L. Paris, Juan Domínguez‐Robles, Lalitkumar K. Vora, Andi Dian Permana, Eneko Larrañeta, Robert P. Graham, Christopher J. Scott, Ryan F. Donnelly
Abstract
assays using DC2.4 mouse dendritic cells showed that hydrogel extracts inhibited cell proliferation without causing cytotoxicity or triggering significant immune responses. These findings highlight the hydrogels' biocompatibility and stability, supporting their potential for biomedical applications.
Topics & Concepts
ImmunogenicitySelf-healing hydrogelsIn vitroComposite numberMaterials scienceChemistryBiomedical engineeringPharmacologyComposite materialMedicineImmunologyBiochemistryPolymer chemistryImmune systemAdvanced Drug Delivery SystemsHydrogels: synthesis, properties, applicationsAdvancements in Transdermal Drug Delivery