Integrating network pharmacology: The next-generation approach in ocular drug discovery
Francesca Lazzara, Federica Conti, Erika Giuffrida, Chiara M. Eandi, Filippo Drago, Chiara Bianca Maria Platania, Claudio Bucolo
Abstract
With the spread of the "omics" sciences, the approaches of systems biology can be considered as new paradigms of pharmacological research for discovery of novel targets and/or treatments for complex multifactorial diseases. Data from omics sciences can be used for the design of biologic networks, that in turn can be quantitatively analyzed to identify new pharmacological targets. In this review, we will introduce the concept of network pharmacology, particularly the application of this innovative approach in the field of ocular pharmacology, with a focus on retinal diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD) and glaucoma.