Elucidating the coordination chemistry of the radium ion for targeted alpha therapy
Alexander S. Ivanov, Megan E. Simms, Vyacheslav S. Bryantsev, Paul D. Benny, Justin Griswold, Lætitia H. Delmau, Nikki A. Thiele
Abstract
To advance the chelation chemistry of the elusive radium ion for targeted radionuclide therapy applications, we report its complexation thermodynamics with the macrocyclic chelators macropa and DOTA.
Topics & Concepts
ChemistryRadiochemistryAlpha (finance)Coordination complexRadium-223IonRadiumMedicineInternal medicineCancerOrganic chemistrySurgeryMetalPatient satisfactionConstruct validityBone metastasisBreast cancerRadiopharmaceutical Chemistry and ApplicationsRadioactive element chemistry and processingChemical Synthesis and Characterization