Litcius/Paper detail

Discovery of a first-in-class Aurora A covalent inhibitor for the treatment of triple negative breast cancer

Bin Zhang, Chengchen Zhu, Albert S. C. Chan, Gui Lu

2023European Journal of Medicinal Chemistry18 citationsDOIOpen Access PDF

Topics & Concepts

Aurora B kinaseAurora inhibitorKinaseChemistryAurora kinaseSerineCancer researchCovalent bondBiochemistryEnzymeCellCell cycleSpindle apparatusBiologyCell divisionOrganic chemistryMicrotubule and mitosis dynamicsProtein Degradation and InhibitorsProtein Structure and Dynamics
Discovery of a first-in-class Aurora A covalent inhibitor for the treatment of triple negative breast cancer | Litcius