Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence
Kevin Pérez, Serban Ciotlos, Julia McGirr, Chandani Limbad, Ryosuke Doi, Joshua P. Nederveen, Mats I. Nilsson, Daniel A. Winer, William J. Evans, Mark A. Tarnopolsky, Judith Campisi, Simon Melov
Abstract
-driven senescence in this subpopulation. Overall, our findings identify unique cellular subpopulations in aged and sarcopenic skeletal muscle, which will facilitate the development of new therapeutic strategies to combat age-related frailty.
Topics & Concepts
SarcopeniaSkeletal muscleTranscriptomeSenescenceBiologyGene expression profilingGene expressionPopulationGeneBioinformaticsCell biologyMedicineGeneticsEndocrinologyEnvironmental healthNutrition and Health in AgingMuscle Physiology and DisordersFrailty in Older Adults