Hydrogen/deuterium exchange mass spectrometry with improved electrochemical reduction enables comprehensive epitope mapping of a therapeutic antibody to the cysteine-knot containing vascular endothelial growth factor
Gerard Comamala, Cornelia Wagner, Pablo Sanz de la Torre, Rasmus U. Jakobsen, Maximiliane Hilger, Hendrik‐Jan Brouwer, Kasper D. Rand
Topics & Concepts
ChemistryHydrogen–deuterium exchangeMass spectrometryCombinatorial chemistryCysteineChromatographyBiophysicsBiochemistryEnzymeBiologyMass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and ApplicationsMonoclonal and Polyclonal Antibodies Research