Residential greenspace and lung function decline over 20 years in a prospective cohort: The ECRHS study
Iana Markevych, Tianyu Zhao, Elaine Fuertes, Alessandro Marcon, Payam Dadvand, Danielle Vienneau, Judith García‐Aymerich, Dennis Nowak, Kees de Hoogh, Deborah Jarvis, Michael J. Abramson, Simone Accordini, André F.S. Amaral, Hayat Bentouhami, Randi Jacobsen Bertelsen, Anne Boudier, Roberto Bono, Gayan Bowatte, Lídia Casas, Shyamali C. Dharmage, Bertil Forsberg, Þórarinn Gíslason, Marco Gnesi, Mathias Holm, Bénédicte Jacquemin, Christer Janson, Rain Jögi, Ane Johannessen, Dirk Keidel, Bénédicte Leynaert, José Antonio Maldonado Pérez, Pierpaolo Marchetti, Enrica Migliore, Jesús Martínez-Moratalla, Hans Orru, Isabelle Pin, James Potts, Nicole Probst‐Hensch, Andrea Ranzi, José Luis Sánchez‐Ramos, Valérie Siroux, David Soussan, Jordi Sunyer, Isabel Urrutia Landa, Simona Villani, Joachim Heinrich
Abstract
The few studies that have examined associations between greenspace and lung function in adulthood have yielded conflicting results and none have examined whether the rate of lung function decline is affected. We explored the association between residential greenspace and change in lung function over 20 years in 5559 adults from 22 centers in 11 countries participating in the population-based, international European Community Respiratory Health Survey. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured by spirometry when participants were approximately 35 (1990–1994), 44 (1999–2003), and 55 (2010–2014) years old. Greenness was assessed as the mean Normalized Difference Vegetation Index (NDVI) in 500 m, 300 m, and 100 m circular buffers around the residential addresses at the time of lung function measurement. Green spaces were defined as the presence of agricultural, natural, or urban green spaces in a circular 300 m buffer. Associations of these greenspace parameters with the rate of lung function change were assessed using adjusted linear mixed effects regression models with random intercepts for subjects nested within centers. Sensitivity analyses considered air pollution exposures. A 0.2-increase (average interquartile range) in NDVI in the 500 m buffer was consistently associated with a faster decline in FVC (−1.25 mL/year [95% confidence interval: −2.18 to −0.33]). These associations were especially pronounced in females and those living in areas with low PM10 levels. We found no consistent associations with FEV1 and the FEV1/FVC ratio. Residing near forests or urban green spaces was associated with a faster decline in FEV1, while agricultural land and forests were related to a greater decline in FVC. More residential greenspace was not associated with better lung function in middle-aged European adults. Instead, we observed slight but consistent declines in lung function parameters. The potentially detrimental association requires verification in future studies.