Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPARγ with potential anti-diabetic efficacy
Fengyu Huang, Zhiping Zeng, Weidong Zhang, Zhiqiang Yan, Jiayun Chen, Liangfa Yu, Qian Yang, Yihuan Li, Hongyu Yu, Junjie Chen, Caisheng Wu, Xiao-kun Zhang, Ying Su, Hu Zhou
Topics & Concepts
RosiglitazoneChemistryTransactivationPeroxisome proliferator-activated receptorSulindacPioglitazonePharmacologyNuclear receptorStereochemistryLigand (biochemistry)ThiazolidinedionePPAR agonistReceptorDiabetes mellitusBiochemistryType 2 diabetesEndocrinologyGene expressionTranscription factorNonsteroidalGeneMedicinePeroxisome Proliferator-Activated ReceptorsInflammatory mediators and NSAID effectsNF-κB Signaling Pathways