Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
Sama I. Sayin, Annika Wahlström, Jenny Felin, Sirkku Jäntti, Hanns–Ulrich Marschall, Krister Bamberg, Bo Angelin, Tuulia Hyötyläinen, Matej Orešič, Fredrik Bäckhed
Topics & Concepts
Bile acidFarnesoid X receptorEnterohepatic circulationCholesterol 7 alpha-hydroxylaseCholic acidIleumGut floraG protein-coupled bile acid receptorBiologyInternal medicineCYP8B1MetabolismFGF19EndocrinologyDeoxycholic acidBiochemistryNuclear receptorReceptorFibroblast growth factorTranscription factorMedicineGeneDrug Transport and Resistance MechanismsPediatric Hepatobiliary Diseases and TreatmentsEpigenetics and DNA Methylation