Sugar-Phosphate Toxicities Attenuate Salmonella Fitness in the Gut
Erin F. Boulanger, Anice Sabag-Daigle, Maryam Baniasad, Katherine Kokkinias, Andrew Schwieters, Kelly Wrighton, Vicki H. Wysocki, Brian M. M. Ahmer
Abstract
, dramatically decrease the fitness of Salmonella in a mouse model of gastroenteritis, suggesting that RhaD, AraD, and MtlD may be good narrow-spectrum drug targets. The induction of sugar-phosphate toxicities may be a therapeutic strategy that is broadly relevant to other bacterial and fungal pathogens.
Topics & Concepts
BiologySalmonellaSugarMicrobiologySugar phosphatesPhosphateBiochemistryBacteriaGeneticsFolate and B Vitamins ResearchSalmonella and Campylobacter epidemiologyVitamin C and Antioxidants Research