Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases
Brian S. Gerstenberger, Catherine M. Ambler, Eric P. Arnold, Mary-Ellen Banker, Matthew F. Brown, James D. Clark, Alpay Dermenci, Martin E. Dowty, Andrew Fensome, Susan Fish, Matthew M. Hayward, Martin Hegen, Brett D. Hollingshead, John D. Knafels, David W. Lin, Tsung H. Lin, Dafydd R. Owen, Eddine Saiah, Raman Sharma, F.F. Vajdos, Lei Xing, Xiaojing Yang, Xin Yang, Stephen W. Wright
Abstract
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Topics & Concepts
Tyrosine kinase 2ADMEChemistryTyrosine kinaseDrug discoveryKinaseSignal transductionReceptorPharmacologyComputational biologyBiochemistryPlatelet-derived growth factor receptorBiologyIn vitroGrowth factorCytokine Signaling Pathways and InteractionsMast cells and histamineMonoclonal and Polyclonal Antibodies Research