A dual-ligand fusion peptide improves the brain-neuron targeting of nanocarriers in Alzheimer's disease mice
Qian Guo, Shuting Xu, Peng Yang, Pengzhen Wang, Shuai Lü, Dongyu Sheng, Kang Qian, Jinxu Cao, Wei Lü, Qizhi Zhang
Topics & Concepts
NanocarriersChemistryPeptideNeuroprotectionBlood–brain barrierLigand (biochemistry)Fusion proteinNeurotoxicityBiophysicsPharmacologyCell biologyDrug deliveryReceptorBiochemistryNeuroscienceBiologyCentral nervous systemToxicityGeneOrganic chemistryRecombinant DNAAlzheimer's disease research and treatmentsRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery