Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology
Livia Odagiu, Julia F. May, Salix Boulet, Troy A. Baldwin, Nathalie Labrecque
Abstract
The nuclear orphan receptors NR4A1, NR4A2, and NR4A3 are immediate early genes that are induced by various signals. They act as transcription factors and their activity is not regulated by ligand binding and are thus regulated via their expression levels. Their expression is transiently induced in T cells by triggering of the T cell receptor following antigen recognition during both thymic differentiation and peripheral T cell responses. In this review, we will discuss how NR4A family members impact different aspects of the life of a T cell from thymic differentiation to peripheral response against infections and cancer.
Topics & Concepts
Neuron-derived orphan receptor 1Nuclear receptorOrphan receptorNerve growth factor IBTranscription factorBiologyReceptorChimeric antigen receptorT-cell receptorT cellCell biologyCellGeneCancer researchGeneticsImmune systemNuclear Receptors and SignalingMacrophage Migration Inhibitory FactorWhipple's Disease and Interleukins