Electrochemical Synthesis of Benzo[<i>d</i>]imidazole via Intramolecular C(sp<sup>3</sup>)–H Amination
An Li, Caohui Li, Tao Yang, Zan Yang, Yu Liu, Lijun Li, Kewen Tang, Congshan Zhou
Abstract
An electrochemical dehydrogenative amination for the synthesis of benzimidazoles was developed. This electrosynthesis method could address the limitations of the C(sp3)-H intramolecular amination synthesis reaction and provide novel access to obtain 1,2-disubstituted benzimidazoles without transition metals and oxidants. Under undivided electrolytic conditions, various benzimidazole derivatives could be synthesized, exhibiting functional group tolerance.
Topics & Concepts
ElectrosynthesisAminationBenzimidazoleIntramolecular forceElectrochemistryChemistryImidazoleCombinatorial chemistryReductive aminationMedicinal chemistryOrganic chemistryCatalysisElectrodePhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques