Local mucosal immunization of self-assembled nanofibers elicits robust antitumor effects in an orthotopic model of mouse genital tumors
Sijin Li, Wenbing Zhu, Chao Ye, Wenjia Sun, Hanghang Xie, Xu Yang, Qishu Zhang, Yanbing Ma
Abstract
T cells were significantly increased in tumor tissues, which may account for the improved recruitment of effector T cells into the tumor. Local mucosal immunization of nanofibers via the intravaginal route represents a new and promising vaccination strategy for the treatment of genital tumor lesions such as cervical cancer.
Topics & Concepts
Cytotoxic T cellTumor microenvironmentMedicineImmunologyImmunizationCXCR3Cancer researchImmunotherapyCD8CXCL10Immune systemChemokineBiologyChemokine receptorIn vitroBiochemistryImmunotherapy and Immune ResponsesRNA Interference and Gene DeliveryVirus-based gene therapy research