Sorafenib induces mitochondrial dysfunction and exhibits synergistic effect with cysteine depletion by promoting HCC cells ferroptosis
Yanchun Li, Jun Xia, Fangchun Shao, Yan Zhou, Jiaqi Yu, Hengyu Wu, Jing Du, Xueying Ren
Topics & Concepts
SorafenibOxidative stressProgrammed cell deathGlutathioneCancer researchApoptosisReactive oxygen speciesChemistryMitochondrionCancer cellMitochondrial ROSCell biologyPharmacologyHepatocellular carcinomaBiologyCancerBiochemistryMedicineInternal medicineEnzymeFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer