Bioactive phenolics fraction of Hedera helix L. (Common Ivy Leaf) standardized extract ameliorates LPS-induced acute lung injury in the mouse model through the inhibition of proinflammatory cytokines and oxidative stress
Aya A. Shokry, Riham A. El‐Shiekh, Gehan M. Kamel, Alaa F. Bakr, Amer Ramadan
Abstract
< 0.05) decreased the pro-inflammatory mediators, and oxidative stress biomarkers induced by LPS. Interestingly, the phenolics showed promising activity, therefore they are responsible for the action. In conclusion, the standardized ivy leaf extract could be advised for acute lung injury for its antimicrobial, anti-oxidant, and anti-inflammatory activities.
Topics & Concepts
Proinflammatory cytokineOxidative stressTraditional medicineHedera helixPharmacologyAntioxidantChemistryMedicineBiologyInflammationImmunologyBiochemistryBotanyMedicinal Plants and Bioactive CompoundsPhytochemistry and Biological ActivitiesAndrographolide Research and Applications