N-benzyl 4,4-disubstituted piperidines as a potent class of influenza H1N1 virus inhibitors showing a novel mechanism of hemagglutinin fusion peptide interaction
Sonia de Castro, Tiziana Ginex, Evelien Vanderlinden, Manon Laporte, Annelies Stevaert, José Cumella, Federico Gago, Marı́a-José Camarasa, F. Javier Luque, Lieve Naesens, Sonsoles Velázquez
Topics & Concepts
ChemistryHemagglutinin (influenza)Influenza A virusPeptidePiperidineVirusLipid bilayer fusionStereochemistryStructure–activity relationshipLead compoundVirologyBiochemistryIn vitroBiologyMembraneInfluenza Virus Research StudiesRNA and protein synthesis mechanismsAntimicrobial Peptides and Activities